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The research found HRS9531 effectively reduced body weight, blood pressure, blood glucose, and triglycerides, with a favorable safety profile

Mice were placed in a stereotaxic frame (Kopf Instruments, USA), and a rectangular craniotomy was performed over the medial prefrontal cortex (AP, 13 mm and ML, 01.5 mm from the bregma) using a dental drill (Microtorque II, Ram Products, USA)

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doi: 10.1083/jcb.200106148 127 HolmesE

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